Bioprospecting and bioassay-guided isolation of medicinal plants-A tool for drug discovery. Chen-Liang Zhao, Wai-I Chik, Hong-Jie Zhang.Uncommon Terpenoids from Salvia Species: Chemistry, Biosynthesis and Biological Activities. Salar Hafez Ghoran, Fatemeh Taktaz, Ali Akbar Mozafari, Murat Tunçtürk, Nazim Sekeroglu, Anake Kijjoa.Current Topics in Medicinal Chemistry 2022, 22 The Antibacterial Activity of Natural-derived Flavonoids. Zhenyou Tan, Jun Deng, Qiongxian Ye, Zhenfeng Zhang.Antibacterial and antibiotic-potentiation activities of the hydro-ethanolic extract and protoberberine alkaloids from the stem bark of Enantia chlorantha against multidrug-resistant bacteria expressing active efﬂux pumps. A significant reduction of ATP production in the presence of 17 was observed in Enterococcus faecalis and E. Molecular modeling studies confirmed the capacity of 17 to interact with mammalian ATP synthase. Terpenoids 10, 11, 15, and 17 inhibited ATP production, while only 17 inhibited also ATP hydrolysis. The compounds were also tested for the inhibition of ATP production in purified mammalian rod outer segments.

The methyl ester of salvileucolide ( 10), salvileucolide-6,23-lactone ( 11), sclareol ( 15), and manool ( 17) were the most active against Gram-positive bacteria. The antimicrobial activity of compounds was evaluated against 30 human pathogens including 27 clinical strains and three isolates of marine origin for their possible implications on human health. The structures of the new compounds were established by 1D and 2D NMR spectroscopy, HRESIMS, and VCD data and Mosher’s esters analysis. A surface extract of the aerial parts of Salvia tingitana afforded a nor-sesterterpenoid ( 1) and eight new sesterterpenoids ( 2–̵ 9), along with five known sesterterpenoids, five labdane and one abietane diterpenoid, one sesquiterpenoid, and four flavonoids.

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